POSH inhibitor complex biomolecules and amphiphile micelles
US11286489B2 · kind B2 · utility
0Cited by
3References
19Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 13, 2017 |
| Grant date | Mar 29, 2022 |
| Priority date | — |
| Expiry date | Jan 16, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/93
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to a composition that includes an amphiphile, its use in a method of preventing and/or treating cancer, and its use in a method of producing a pharmaceutical composition. In certain embodiments, the amphiphile includes a hydrophilic peptide that binds to a Plenty of SH3 domain (POSH) and inhibits or disrupts a POSH scaffold network, a hydrophobic moiety, and an aptamer. The present invention is also directed to other POSH inhibitor complex biomolecules that do not contain a hydrophobic moiety.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.