Patent · US Active

Method for preparing troxerutin ester using whole-cell catalysis

US11286511B2 · kind B2 · utility

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7Claims

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Assignee

South China University of Technology · CN

Inventors

Xiaofeng Li · Plano, US
Xuan Xin · Tangxia, CN
Guanglei Zhao · Qinhuangdao City, CN

Key dates

Filing date	Nov 30, 2017
Grant date	Mar 29, 2022
Priority date	—
Expiry date	Mar 31, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N1/20
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method for preparing troxerutin ester using whole-cell catalysis belongs to the fields of biological catalysis and pharmaceutical chemistry. The method specifically includes the following steps: evenly mixing troxerutin and a mixed organic solvent containing pyridine, then adding an acyl donor and a whole-cell catalyst, and performing a reaction under oscillation at a reaction temperature of 25° C. to 55° C.; and after the reaction is finished, separating and purifying a product by column chromatography or thin-layer chromatography, so as to obtain the troxerutin ester. The invention has the advantages of mild reaction conditions, environmental friendliness, simple process, fewer side reactions and high selectivity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.