Patent · US Active

Assaying ovarian cyst fluid

US11286531B2 · kind B2 · utility

0Cited by

152References

23Claims

0Family size

Assignee

THE JOHNS HOPKINS UNIVERSITY · US

Inventors

Yuxuan Wang · Baltimore, US
Bert Vogelstein · Baltimore, US
Kenneth W. Kinzler · Baltimore, US
Luis Diaz · Ellicott City, US
Nickolas Papadopoulos · Towson, US
Karin Sundfeldt · Gothenburg, SE
Bjorg Kristjansdottir · Gothenburg, SE

Key dates

Filing date	Aug 11, 2016
Grant date	Mar 29, 2022
Priority date	—
Expiry date	Mar 18, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/156
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A diagnostic test for ovarian cysts is based on the detection of mutations characteristic of the most common neoplasms giving rise to these lesions. With this test, tumor-specific mutations were detected in the cyst fluids of 19 of 24 (79%) borderline tumors and 28 of 31 (90%) malignant ovarian cancers. In contrast, we detected no mutations in the cyst fluids from 10 non-neoplastic cysts and 12 benign tumors. When categorized by the need for exploratory surgery (i.e., presence of a borderline tumor or malignant cancer), the sensitivity of this test was 85% and the specificity was 100%. These tests could inform the diagnosis of ovarian cysts and improve the clinical management of the large number of women with these lesions.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.