Virion-like delivery particles for self-replicating RNA molecules
US11291635B2 · kind B2 · utility
41Cited by
31References
7Claims
0Family size
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Key dates
| Filing date | Jul 6, 2011 |
| Grant date | Apr 5, 2022 |
| Priority date | — |
| Expiry date | Jul 6, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Nucleic acid immunisation is achieved by delivering a self-replicating RNA encapsulated within a small particle. The RNA encodes an immunogen of interest, and the particle may deliver this RNA by mimicking the delivery function of a natural RNA virus. Thus the invention provides a non-virion particle for in vivo delivery of RNA to a vertebrate cell, wherein the particle comprises a delivery material encapsulating a self-replicating RNA molecule which encodes an immunogen. These particles are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.