Patent · US Active

Methods and compositions for producing hepatocyte-like cells

US11291691B2 · kind B2 · utility

0Cited by

0References

12Claims

0Family size

Assignee

The Board of Trustees of the Leland Stanford Junior University · US

Inventors

Gary Peltz · Redwood City, US
Dan Xu · Nanjing, CN

Key dates

Filing date	May 8, 2018
Grant date	Apr 5, 2022
Priority date	—
Expiry date	Jul 28, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2533/90
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods are provided for producing a population of hepatocyte-like cells (iHeps) from a population of adipocyte-derived stem cells (ASCs). Aspects of the methods include placing a population of ASCs into a three dimensional culture (e.g., hanging drop suspension culture, high density culture, spinner flask culture, microcarrier culture, etc.), and contacting the cells with a first and second culture medium. Also provided are methods of treating an individual, which include producing a population of iHeps from a population of ASCs, and administering an effective number of iHeps into the individual. Kits for practicing the methods are also described herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.