Small molecule inhibitors of BCL-2-associated death promoter (BAD) phosphorylation

US11292773B2 · kind B2 · utility

Assignees

• NATIONAL UNIVERSITY OF SINGAPORE · SG
• UNIVERSITY OF MYSORE · IN
• BANGALORE UNIVERSITY · IN

Inventors

• Peter Edward Lobie · Singapore, SG
• Vijay Kumar Pandey · Singapore, SG
• Rangappa Kanchugarakoppal Subbegowda · Mumbai, IN
• Bassappa Salundi · Bengaluru, IN
• Mohan Chakrabhavi Dhananjaya · Mumbai, IN
• Shobith Rangappa · Mumbai, IN
• Srinivasa Venkatachalaiah · Bengaluru, IN

Key dates

• Filing date: Apr 18, 2018
• Grant date: Apr 5, 2022
• Expiry date: Apr 18, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to compounds of general formula (I): wherein R1, n, R2a, R2b, and R3 are as defined herein. The compounds are inhibitors of Bcl-2-associated death promoter (BAD) phosphorylation and have anti-apoptotic activity and are useful in the treatment of cancer, particularly breast cancer, endometrial cancer, ovarian cancer, liver cancer, colon cancer, prostate cancer or pancreatic cancer.