Long-acting prodrugs of entecavir, preparing methods and uses thereof

US11292811B2 · kind B2 · utility

Assignee

• GUANGZHOU HENOVCOM BIOSCIENCE CO., LTD. · CN

Inventors

• Jiancun Zhang · Dongguan, CN
• Deyao Li · 流花街道, CN
• Yiqian ZHOU · 流花街道, CN
• Yiwu Wu · 流花街道, CN
• Yan Liu · Tangshan City, CN

Key dates

• Filing date: Sep 29, 2018
• Grant date: Apr 5, 2022
• Expiry date: Sep 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07J43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are a long-acting prodrug of Entecavir, preparation method and use thereof, wherein the prodrug of Entecavir has a structure of formula I. The prodrug of Entecavir can be released slowly, sustainably and steady, and converted to active compound of Entecavir to achieve a long-acting effect.