Patent · US Active

Bispecific antibodies binding ALK-1 and BMPR-2

US11292846B2 · kind B2 · utility

0Cited by

8References

2Claims

0Family size

Assignee

BAYER HEALTHCARE LLC · DE

Inventors

Ernst Weber · Langenfeld, DE
Joerg Meding · Wuppertal, DE
Florian Sohler · Essen, DE
Julian Marius Glueck · Essen, DE

Key dates

Filing date	Oct 25, 2018
Grant date	Apr 5, 2022
Priority date	—
Expiry date	Nov 30, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Bispecific antibodies binding ALK-1 and BMPR-2 The present invention relates to bispecific antibodies binding human ALK-1 and human BMPR-2. Also provided are BsABs which are agonists of ALK-1/BMPR-2 signaling, and BsABs which do not trigger osteogenic signaling. Furthermore, the invention relates to pharmaceutical uses of the BsABs, in particular for the treatment of pulmonary hypertension. Also provided are methods to screen for BsABs for use in the therapy, e.g. of pulmonary hypertension.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.