Chimeric genome engineering molecules and methods
US11293019B2 · kind B2 · utility
2Cited by
3References
26Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Dec 21, 2018 |
| Grant date | Apr 5, 2022 |
| Priority date | — |
| Expiry date | Dec 21, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure provides compositions and methods for increasing mutation efficiency and homologous recombination rates of site-specific endonucleases. The compositions and methods comprise a chimeric polypeptide comprising a site-specific endonuclease or a domain thereof and a functional moiety. The current inventions relate to functional enhancement of the CRISPR-Cas enzymes. Disclosed herein include possible variants and their intended improvements.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.