Patent · US Active

S-layer protein 2D lattice coupled detergent-free GPCR bioelectronic interfaces, devices, and methods for the use thereof

US11293923B2 · kind B2 · utility

0Cited by

1References

25Claims

0Family size

Assignee

Massachusetts Institute of Technology · US

Inventors

Shuguang Zhang · Lexington, US
Rui Qing · Somerville, US
Andreas Breitwieser · Wien, AT
Uwe Sleytr · Wien, AT

Key dates

Filing date	Aug 31, 2018
Grant date	Apr 5, 2022
Priority date	—
Expiry date	Nov 10, 2038

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/20
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor or device comprising the bioelectronic interface and methods of screening for a ligand of a GPCR.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.