Prodrugs of substituted triazole derivatives and uses thereof

US11298367B2 · kind B2 · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Marie-Pierre Collin-Kroepelin · Wuppertal, DE
• Peter Kolkhof · Wuppertal, DE
• Thomas Neubauer · Wuppertal, DE
• Chantal Fuerstner · Neheim, DE
• Elisabeth Pook · Wuppertal, DE
• Matthias Beat WITTWER · Riehen, CH
• Carsten Schmeck · Wuppertal, DE
• Pierre Wasnaire · Mülheim an der Ruhr, DE
• Heiko Schirmer · Solingen, DE
• Hana Cernecka · Wuppertal, DE
• Karoline Droebner · Velbert, DE
• Hanna Tinel · Wuppertal, DE
• Anja BUCHMUELLER · Essen, DE
• Thomas MONDRITZKI · Essen, DE
• Axel Kretschmer · Wuppertal, DE
• Klemens Lustig · Wuppertal, DE
• Robert Fricke · Cologne, DE
• Guillaume Levilain · Wuppertal, DE
• Ursula Krenz · Leichlingen, DE
• Norbert Witowski · Wolfenbüttel, DE

Key dates

• Filing date: Oct 17, 2018
• Grant date: Apr 12, 2022
• Expiry date: Apr 4, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65583
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.