Prodrugs comprising a pyroglutamate linker

US11298427B2 · kind B2 · utility

Assignees

• ASCENDIS PHARMA A/S · DK
• Ascendis Pharma Inc. · DE

Inventors

• Harald Rau · Würzburg, DE
• Nicola Bisek · Heidelberg, DE
• Samuel Weisbrod · Heidelberg, DE

Key dates

• Filing date: May 25, 2016
• Grant date: Apr 12, 2022
• Expiry date: Nov 17, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/60
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel prodrugs of primary or secondary amine-comprising biologically active moieties and pharmaceutically acceptable salts thereof, prodrug reagents, pharmaceutical compositions comprising said prodrugs and the use of prodrugs.