Antagonists of the muscarinic acetylcholine receptor M4

US11299481B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Craig W. Lindsley · Brentwood, US
• P. Jeffrey Conn · Brentwood, US
• Darren W. Engers · Brentwood, US
• Julie L. Engers · Brentwood, US
• Kayla J. Temple · Spring Hill, US
• Aaron M. Bender · Spring Hill, US
• Logan A. Baker · Thompson's Station, US

Key dates

• Filing date: Oct 20, 2018
• Grant date: Apr 12, 2022
• Expiry date: Oct 20, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D493/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are substituted hexahydro-1H-cyclopenta[c]pyrrole compounds, which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.