Orthoester compositions for affinity purification of oligonucleotides
US11299483B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Aug 17, 2018 |
| Grant date | Apr 12, 2022 |
| Priority date | — |
| Expiry date | Oct 7, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H1/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can be then removed under mild conditions to generate the target oligonucleotide in high purity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.