Preparation method and application of isoxazinone compounds

US11299499B2 · kind B2 · utility

Assignee

• ZHEJIANG ZHUJI UNITED CHEMICALS CO., LTD. · CN

Inventors

• Qiuju Sheng · Zhejiang, CN
• Baochuan Guan · Zhejiang, CN
• Tianhao Zhang · Raleigh, US
• Pan Zhang · 红钢城街道, CN
• Jinlong Zhang · 红钢城街道, CN
• Bangchi Chen · Hangzhou City, CN

Key dates

• Filing date: Nov 25, 2019
• Grant date: Apr 12, 2022
• Expiry date: Jan 28, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are a preparation method and an application of an isoxazinone compound (I), where the preparation method includes: reacting compound (II) with a carboxylic acid (III) in the presence of a dehydrating agent and a base to produce the isoxazinone compound (I); and subjecting the isoxazinone compound (I) and a protonic acid salt of an amino compound (IV) or R3OH (VII) to ring-opening reaction in the presence of a base to produce a bisamide compound (V) or an N-acyl benzoate compound (VI).