Methods for selective expansion of γδ T-cell populations and compositions thereof

US11299708B2 · kind B2 · utility

Assignee

• ADICET BIO, INC. · US

Inventors

• Aya Jakobovits · Beverly Hills, US
• Orit Foord · Foster City, US
• Andy An-deh Lin · Palo Alto, US
• Marianne Theresa Santaguida · Redwood City, US
• Radhika Desai · Brisbane, US
• Yifeng Frank Jing · Hayward, US
• Daulet Kadyl Satpayev · Santa Monica, US
• Yan Li · Tianjin, CN

Key dates

• Filing date: May 12, 2017
• Grant date: Apr 12, 2022
• Expiry date: Dec 26, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods for the selective expansion of γδ T-cell population(s), compositions and admixtures thereof and methods for using the same as a therapeutic. Non-engineered and engineered, enriched γδ T-cell populations of the disclosure are useful in the treatment of various cancers, infectious diseases, and immune disorders.