Cultured transgenic cell allowing growth of norovirus, and use thereof
US11299750B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Feb 1, 2017 |
| Grant date | Apr 12, 2022 |
| Priority date | — |
| Expiry date | Dec 9, 2038 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/08
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
An object of the present invention is to solve problems in terms of stagnation of research on norovirus by providing a cultured transgenic cell or a transgenic animal in which murine norovirus (MNV) can be grown across the barrier of host specificity in mammalian cells, and providing a screening method that uses the cultured transgenic cell or the transgenic animal. The present inventors have found that MNV infection is determined in a cultured transgenic mammalian cell or a mammal possessing the cultured transgenic mammalian cell as its own cell, the cultured transgenic mammalian cell containing one or more species selected from the entirety or a portion of the murine CD300F gene and/or a CD300 family gene having an extracellular domain nucleotide sequence similar to that of the murine CD300F gene. The present inventors have solved the aforementioned problems by providing, for example, a norovirus-related drug screening method on the basis of this finding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.