Binding molecules specific for HER3 and uses thereof

US11305012B2 · kind B2 · utility

Assignee

• MedImmune Limited · US

Inventors

• Partha S. Chowdhury · Gaithersburg, US
• David Tice · Gaithersburg, US
• Zhan Xiao · Boyds, US
• Philipp Steiner · Washington, US
• Krista Kinneer · Montgomery Village, US
• Marlon Rebelatto · Gaithersburg, US
• Andrew Pierce · Westfield, GB

Key dates

• Filing date: Sep 23, 2014
• Grant date: Apr 19, 2022
• Expiry date: Dec 2, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are antibodies and antigen binding fragments thereof that bind the extracellular domain of the HER3 receptor and inhibit various HER3 receptor related functions via ligand-dependent and/or ligand-independent mechanisms. Also provided are compositions with increased half-life, as well as compositions and methods for diagnosing and treating diseases associated with HER3 mediated signal transduction.