Bioprosthetic tissue having a reduced propensity for in vivo calcification
US11305036B2 · kind B2 · utility
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67References
20Claims
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Key dates
| Filing date | Oct 7, 2019 |
| Grant date | Apr 19, 2022 |
| Priority date | — |
| Expiry date | Jul 29, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/40
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A bioprosthetic tissue having a reduced propensity to calcify in vivo, the bioprosthetic tissue. The bioprosthetic tissue comprises an aldehyde cross-linked and stressed bioprosthetic tissue comprising exposed calcium, phosphate or immunogenic binding sites that have been reacted with a calcification mitigant. The bioprosthetic tissue has a reduced propensity to calcify in vivo as compared to aldehyde cross-linked bioprosthetic tissue that has not been stressed and reacted with the calcification mitigant.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.