Patent · US Active

Benzothia(di)azepine compounds and their use as bile acid modulators

US11306064B2 · kind B2 · utility

12Cited by

64References

21Claims

0Family size

Assignee

ALBIREO AB · SE

Inventors

Per-Göran Gillberg · Timrå, SE
Jan Mattsson · Gothenburg, SE
Ingemar Starke · Gothenburg, SE
Santosh S. Kulkarni · Kanchinakote, IN

Key dates

Filing date	Aug 4, 2020
Grant date	Apr 19, 2022
Priority date	—
Expiry date	Aug 4, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D285/36
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to 1,5-benzothiazepine and 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.