Gamma-carboline compounds for the detection of Tau aggregates

US11306089B2 · kind B2 · utility

Assignee

• LIFE MOLECULAR IMAGING LIMITED · BM

Inventors

• Mathias Berndt · Berlin, DE
• Andre Müller · Berlin, DE
• Felix Oden · Berlin, DE
• Hanno Schieferstein · Berlin, DE
• Heribert Schmitt-Willich · Berlin, DE
• Heiko Kroth · Ecublens, CH
• Jerome Molette · Ferney-Voltaire, FR

Key dates

• Filing date: Jan 22, 2019
• Grant date: Apr 19, 2022
• Expiry date: Jan 22, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to novel compounds of the formula (II) and formula (III) that can be employed in the selective Tau detection of disorders and abnormalities associated with Tau aggregates such as Alzheimer's disease and other tauopathies using Positron Emission Tomography (PET) Imaging.