Amino indole compounds useful as TLR inhibitors

US11306092B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Alaric J. Dyckman · Lawrenceville, US
• Dharmpal S. Dodd · Princeton, US
• Christopher P. Mussari · Princeton, US
• David R. Tortolani · Skillman, US
• Tasir Shamsul Haque · Yardley, US
• Shoshana L. Posy · Highland Park, US

Key dates

• Filing date: Dec 19, 2018
• Grant date: Apr 19, 2022
• Expiry date: Dec 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds of Formula (I) or salts thereof, wherein G, R1, R5, R7, R8, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.