Method of treating bone metastasis diseases, medicaments therefore, and a method of predicting the clinical outcome of treating bone metastasis diseases

US11306146B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Josef Straub · Seeheim-Jugenheim, DE
• Eike Staub · Darmstadt, DE

Key dates

• Filing date: Jul 22, 2019
• Grant date: Apr 19, 2022
• Expiry date: Jul 22, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/52
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method is used for treating bone metastasis diseases in subjects. The method preferably depends on whether the subject shows certain specific proteins levels in one or more body fluids prior to or during treatment. The treatment includes the administration of at least one pan αv integrin inhibitor to a subject, a medicament for use in said new methods, and a method of predicting the outcome of a treatment with at least one pan αv integrin inhibitor based on the specific protein levels in one or more body fluids of the subject.