Patent · US Active

Functionalized metal-labeled beads for mass cytometry

US11307206B2 · kind B2 · utility

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9Claims

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Assignee

DEUTSCHES RHEUMA-FORSCHUNGSZENTRUM BERLIN · DE

Inventors

Henrik Mei · Berlin, DE
Axel Schulz · Emmelshausen, DE
Lisa Budzinski · Berlin, DE

Key dates

Filing date	Apr 25, 2019
Grant date	Apr 19, 2022
Priority date	—
Expiry date	Jun 30, 2039

Classification

Technology area (CPC G)Physics
CPC primaryG01N2560/00
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Beads for use as a control, calibration and/or quantification probe in a mass cytometry assay, wherein the beads are labeled with a heavy metal selected from the group comprising osmium or ruthenium. Also disclosed are beads labeled with a heavy metal exhibiting a surface functionalization that allows for the binding of an affinity reagent, such as a metal-conjugated antibody. Methods are described for the labeling of the beads and usage of the beads for quantification of cell surface receptors or for a compensation of channel crosstalk in mass cytometry assays.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.