Methods and compositions for treating skin afflictions
US11311484B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 30, 2019 |
| Grant date | Apr 26, 2022 |
| Priority date | — |
| Expiry date | Apr 30, 2039 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5068
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a method for treating skin afflictions in a subject comprising a step of administering said subject with a therapeutically effective amount of small extracellular vesicles (sEV) comprising CD98hc. Inventors have demonstrated that healthy dermal fibroblasts produced and secreted EVs bearing characteristic of exosome-like small EVs (sEVs). They have shown that CD98hc was present at the surface of sEVs, transferred and stabilized at the plasma membrane of recipient cells. They observed that the transferred protein was functional both in vitro and in vivo. Furthermore, injection of sEVs in epidermal CD98hc KO mice exhibiting wound healing defect rescued wound closure in vivo. Thus, their findings reveal that CD98hc contained in EVs could potentially be used in vivo to treat and improve multiple skin afflictions by allowing protein rescue.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.