Components with high API loading

US11311489B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Carlo Giovanni Traverso · Newton, US
• Alex G. Abramson · Chesterfield, US
• Ester Caffarel Salvador · Cambridge, US
• Niclas Roxhed · Cambridge, US
• Minsoo Khang · Boston, US
• Taylor Bensel · Walpole, US
• Robert S. Langer · Newton, US

Key dates

• Filing date: May 17, 2018
• Grant date: Apr 26, 2022
• Expiry date: May 17, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/0509
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.