Genetically modified non-human animal with human or chimeric PD-L1

US11317611B2 · kind B2 · utility

Assignee

• Biocytogen Pharmaceuticals (Beijing) Co., Ltd. · CN

Inventors

• Yuelei Shen · Beijing, CN
• Yang Bai · Beijing, CN
• Yanan Guo · Beijing, CN
• Rui Huang · Beijing, CN
• Xiaofei Zhou · Beijing, CN
• Chaoshe Guo · Beijing, CN

Key dates

• Filing date: Aug 30, 2017
• Grant date: May 3, 2022
• Expiry date: Aug 30, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/8509
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Non-human animals, methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanized programmed death-ligand 1 (PD-L1, PDL1, or B7-H1). Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous PD-L1 gene so that the non-human animals express a humanized PD-L1 protein that includes a human portion and an endogenous portion (e.g., a non-human portion).