Patent · US Active

6-6 bicyclic aromatic ring substituted nucleoside analogues for use as PRMT5 inhibitors

US11318157B2 · kind B2 · utility

1Cited by

2References

4Claims

0Family size

Assignee

Janssen Pharmaceuticals, Inc. · BE

Inventors

Tongfei Wu · Leuven, BE
Dirk Brehmer · Glückstadt, DE
Lijs Beke · Ekeren, BE
An Boeckx · Herentals, BE
Gaston Stanislas Marcella Diels · Turnhout, BE
Ronaldus Arnodus Hendrika Joseph Gilissen · Beerse, BE
Edward C. Lawson · Pipersville, US
Vineet Pande · Vosselaar, BE
Marcus Cornelis Bernardus Catharina Paradé · Eindhoven, NL
Wim Bert Griet Schepens · Sint-Katelijne-Waver, BE
Johannes Wilhelmus John F. Thuring · Ekeren, BE
Marcel Viellevoye · Breda, NL
Weimei Sun · North Wales, US
Lieven Meerpoel · Beerse, BE

Key dates

Filing date	Mar 20, 2020
Grant date	May 3, 2022
Priority date	—
Expiry date	Mar 20, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D471/04
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Embodiments of the present invention relate to 6-6 bicyclic aromatic ring substituted nucleoside analogues, including, for example, the following compound:Embodiments of the present invention also relate to uses of the disclosed compounds for the inhibition of protein arginine methyltransferase 5 (PRMT5).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.