Method for non surgical repair of vertebral compression fractures

US11318166B2 · kind B2 · utility

Assignee

• Cedars Sinai Medical Center · US

Inventors

• Dan Gazit · Modiin-Maccabim-Reut, IL
• Edward M. Schwarz · Rochester, US
• Hyun Joo BAE · Los Angeles, US
• Gadi Pelled · Los Angeles, US
• Zulma Gazit · Los Angeles, US
• Dmitriy Sheyn · Los Angeles, US
• Wafa Tawackoli · Beverly Hills, US

Key dates

• Filing date: Jun 4, 2015
• Grant date: May 3, 2022
• Expiry date: Oct 12, 2035

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are methods and compositions using PTH and mesenchymal stem cells (MSCs) for treatment of osteoporosis, bone fractures, and related conditions. Administration of both PTH and MSCs leads to increased homing of MSCs to sites of vertebral bone and rib fracture. The described methods and compositions provide therapeutic approaches that rely, in-part, on stem cell capacity for regeneration and repair. The potential for enhanced bone formation and fracture repair may allow for both preventative and palliative treatments in osteoporotic patients, with combined PTH+MSC therapy producing bone regeneration capacity that is significantly superior to either treatment alone.