Systems and methods for improved tissue-sensing based electroporation

US11318305B2 · kind B2 · utility

Assignee

• OncoSec Medical Incorporated · US

Inventors

• Arya Bahrami · Village of La Jolla, US
• Douglas W. Brown · San Diego, US
• Jean Campbell · Seattle, US
• Richard J. Connolly · Riverview, US
• Andy Edward Denison · Temecula, US
• Christopher Scott Hayden · Winchester, US
• Eric T. Johnson · Temecula, US
• Robert H. Pierce · Seattle, US
• Robert Ryan Ragland · Temecula, US

Key dates

• Filing date: Mar 31, 2016
• Grant date: May 3, 2022
• Expiry date: Mar 26, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/0424
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

An adaptive control method for controlling EP pulse parameters during electroporation (EP) of cells or tissue using an EP system includes providing a system for adaptive control to optimize EP pulse parameters including EP pulse parameters, applying voltage and current excitation signals to the cells, obtaining data from the current and voltage measurements, and processing the data to separate the desirable data from the undesirable data, extracting relevant features from the desirable data, applying at least a portion of the relevant features to a trained diagnostic model, estimating EP pulsing parameters based on an outcome of the applied relevant features, where the initialized EP pulsing parameters are based on the trained model and the relevant features, to optimize the EP pulsing parameters, and applying, by the generator, a first EP pulse based on the first pulsing parameters.