Substituted aryl ether compound, preparation method thereof, pharmaceutical composition and use thereof

US11319322B2 · kind B2 · utility

Assignee

• XIAMEN UNIVERSITY · CN

Inventors

• Xianming Deng · Fujian, CN
• Ting Zhang · Shanghai, CN
• Qiaofeng Kang · Xiamen, CN
• Yanru Yang · Xiamen, CN
• Xihuan Sun · Xiamen, CN
• Zaiyou Yang · Xiamen, CN
• Xiaoyang Li · Fremont, US
• Jingfang Zhang · Xiamen, CN
• Jiaji Zhong · Xiamen, CN
• Zhou Deng · Beijing, CN
• Chao Dong · Beijing, CN
• Shuang LIU · Xiamen, CN
• Li Li · Stanford, US
• Qingyan Xu · Xiamen, CN
• Zhiyu Hu · Beijing, CN

Key dates

• Filing date: Jun 29, 2018
• Grant date: May 3, 2022
• Expiry date: Jun 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound having the following formula, or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof, preparation method thereof, pharmaceutical composition comprising the same and use of the compound in the manufacture of a medicament for preventing or treating tumor, wherein the substituents are as defined in the specification.