Tricyclic fused derivatives of 1-(cyclo)alkyl pyrtdin-2-one useful for the treatment of cancer

US11319326B2 · kind B2 · utility

Assignee

• JUBILANT BIOSYS LIMITED · IN

Inventors

• Saravanan Vadivelu · Bengaluru, IN
• Sridharan Rajagopal · Bengaluru, IN
• Murugan CHINNAPATTU · Bengaluru, IN
• Pavan Kumar Gondrala · Bengaluru, IN
• Dhanalakshmi Sivanandhan · Noida, IN
• Chandrika Mulakala · Bengaluru, IN

Key dates

• Filing date: May 7, 2020
• Grant date: May 3, 2022
• Expiry date: May 7, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2300/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure described heterocyclic compounds of Formula I or, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivative thereof and pharmaceutical compositions containing them as the active ingredient. The present disclosure also describes the synthesis and characterization of aforementioned compounds to exhibit high anticancer activity. The compounds of the present disclosure are useful as medicaments and their use in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by one or more BET family of bromodomains.