Template-directed PNA synthesis process and PNA targeting compounds

US11319349B2 · kind B2 · utility

Assignee

• CARNEGIE MELLON UNIVERSITY · US

Inventors

• Danith H. Ly · Pittsburgh, US
• Raman Bahal · Glastonbury, US
• Dinesh Chandra Bhunia · Pittsburgh, US
• Yidan Cong · Gaithersburg, US
• Arunava Manna · Pittsburgh, US
• Srinivas Rapireddy · Westborough, US

Key dates

• Filing date: Jan 17, 2019
• Grant date: May 3, 2022
• Expiry date: Jan 18, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6806
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Described herein are recognition modules that bind specifically to a template nucleic acid and which ligate together in a reducing environment to produce a gamma peptide nucleic acid (γPNA) oligomer. Also provided are methods of synthesizing a γPNA oligomer on a template using the recognition modules.