Method and apparatus for screening compounds that have preventative and therapeutic activities against endothelial glycocalyx-related diseases
US11319519B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 12, 2019 |
| Grant date | May 3, 2022 |
| Priority date | — |
| Expiry date | May 31, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12M41/48
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The microfluidic chip can comprise at least one multichamber flow assembly that can comprise a plurality of microchannels. The plurality of microchannels can comprise a first microchannel that includes: a first inlet; a first outlet; and a first chamber fluidly connected to the first inlet and the first outlet. The plurality of microchannels can comprise a second microchannel that includes: a second inlet; a second outlet; and a second chamber fluidly connected to the second inlet and the second outlet. The multichamber flow assembly can comprise a porous biocompatible membrane oriented along a longitudinal interface between the first microchannel and the second microchannel, wherein the porous biocompatible membrane is permeable for movement of biomolecules from the first chamber to the second chamber through the porous biocompatible membrane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.