Methods for the detection of genomic copy changes in DNA samples
US11319594B2 · kind B2 · utility
2Cited by
76References
56Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 2017 |
| Grant date | May 3, 2022 |
| Priority date | — |
| Expiry date | Aug 24, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7028
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention includes compositions and methods useful for the detection of a mutational change, SNP, translocation, inversion, deletion, change in copy number, or other genetic variation within a sample of cellular genomic DNA or cell-free DNA (cfDNA). In some embodiments, the compositions and methods of the present invention provide an extremely high level of resolution that is particularly useful in detecting copy number variations in a small fraction of the total cfDNA from a biological sample (e.g., blood).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.