Isotopic methods for measurement of tryptophan and metabolites thereof

US11320438B2 · kind B2 · utility

Assignees

• ELECTROPHORETICS LIMITED · GB
• RUPRECHT-KARLS-UNIVERSITAT · DE
• DKFZ DEUTSCHES KREBSFORSCHUNGSZENTRUM · DE

Inventors

• Sasa Koncarevic · Schweinfurt, DE
• Karsten Kuhn · Dortmund, DE
• Peter Schulz-Knappe · Hemmingen, DE
• Ian Hugo Pike · London, GB
• Christiane Opitz · Weinheim, DE
• Michael Platten · Heidelberg, DE

Key dates

• Filing date: Oct 31, 2016
• Grant date: May 3, 2022
• Expiry date: Jun 12, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2458/15
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Tryptophan degradation is a key metabolic pathway controlling immune reactions and evidence suggests that during cancer progression generation of tryptophan metabolites may be fundamental for immune escape promoting the malignant phenotype of cancer cells in an autocrine fashion. The present invention relates to methods of measuring mass tag labelled tryptophan and metabolites thereof and methods using the labelled molecules for monitoring in a subject the effectiveness of a treatment and of disease recurrence after treatment, for stratifying patients and for diagnosing suppression of an immune response in a subject.