Synthetic DNA vectors and methods of use
US11324839B2 · kind B2 · utility
3Cited by
16References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 1, 2021 |
| Grant date | May 10, 2022 |
| Priority date | — |
| Expiry date | Jul 1, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are isolated DNA vectors comprising a heterologous gene, wherein the DNA vector is devoid of bacterial plasmid DNA and/or bacterial signatures, which can abrogate persistence in vivo. The invention also features pharmaceutical compositions (non-immunogenic pharmaceutical compositions) including the DNA vectors of the invention, which can be used for induction of long-term, episomal expression of a heterologous gene in a subject. The invention involves methods of treating a subject by administering the DNA vectors of the invention, including methods of treating disorders associated with a defect in a target gene.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.