Biomaterials for enhanced implant-host integration

US11324858B2 · kind B2 · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• Massachusetts Institute of Technology · US

Inventors

• Christopher S. Chen · Wallingford, US
• Jan D. Baranski · Philadelphia, US
• Ritika Chaturvedi · Philadelphia, US
• Michael T. Yang · Princeton Colonial Park, US
• Kelly R. Stevens · Seattle, US
• Sangeeta N. Bhatia · Lexington, US

Key dates

• Filing date: Mar 26, 2021
• Grant date: May 10, 2022
• Expiry date: Mar 26, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.