Implants for localized drug delivery and methods of use thereof

US11324935B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Pamela Munster · Hillsborough, US
• Jim Kiriakis · Corte Madera, US
• Hani Sbitany · San Francisco, US
• Scott Thomas · Oakland, US

Key dates

• Filing date: Feb 12, 2019
• Grant date: May 10, 2022
• Expiry date: Feb 12, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein is an implant for delivering a hydrophobic active agent to a target tissue. The implant may include a scaffold defining a first surface and a second surface opposite the first surface, wherein the scaffold is substantially impermeable to the hydrophobic active agent, and a silicone tubing having a wall permeable to the hydrophobic active agent, wherein a first length of the silicone tubing is affixed to the first surface of the scaffold, wherein two ends of the silicone tubing extend from the first surface, and wherein a path outlined by a second length of the silicone tubing within the first length is circuitous. Also provided is a method of using the implant to locally deliver the hydrophobic active agent to the target tissue, and kits that find use in performing the present method.