Antagonists of the muscarinic acetylcholine receptor M4

US11325896B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Craig W. Lindsley · Brentwood, US
• P. Jeffrey Conn · Brentwood, US
• Darren W. Engers · Brentwood, US
• Aaron M. Bender · Spring Hill, US
• Logan A. Baker · Thompson's Station, US

Key dates

• Filing date: Dec 20, 2018
• Grant date: May 10, 2022
• Expiry date: Dec 20, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are substituted 2-azaspiro[3.3]heptane compounds of formula (I′), which may be useful as antagonists of the muscarinic acetylcholine receptor M4 (mAChR M4). Also disclosed herein are methods of making the compounds, pharmaceutical compositions comprising the compounds, and methods of treating disorders using the compounds and compositions.