Small molecule inducers of autophagy

US11325898B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jef De Brabander · Dallas, US
• Qiren Liang · Dallas, US
• Beth C. Levine · Dallas, US
• Wei-Chung Chiang · Dallas, US

Key dates

• Filing date: Dec 4, 2020
• Grant date: May 10, 2022
• Expiry date: Jan 11, 2041

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Small molecule disruptors of Beclin-1/Bcl-2 protein-protein interactions induce autophagy and hence are useful for treating a variety of indications where stimulation of autophagy is therapeutically useful, including cancer, infection immunity, neurodegeneration, longevity.