Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases

US11325903B2 · kind B2 · utility

Assignee

• Bantam Pharmaceutical, LLC · US

Inventors

• M. Arshad Siddiqui · Newton, US
• Stephane Ciblat · Montréal, CA
• Martin Dery · Montréal, CA
• Lea Constantineau-Forget · Montréal, CA
• Chantal Grand-Maitre
• Nicolas Bruneau-Latour · Montréal, CA
• Gerald W. Shipps, Jr. · Stoneham, US
• Alan B. Cooper · West Caldwell, US
• Vibha Oza · Acton, US
• Matthew J. Kostura · Hillsborough, US
• Michael Luther · Andover, US
• Jedd Levine · Litchfield, US

Key dates

• Filing date: Nov 29, 2017
• Grant date: May 10, 2022
• Expiry date: Nov 29, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D451/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds useful, for example, in methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formulae (Ia), (Ib), (Ic), (Id) and (Ie), in which R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.