System and method for synthesis of DNA particles and use thereof
US11326196B2 · kind B2 · utility
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Key dates
| Filing date | Jan 10, 2017 |
| Grant date | May 10, 2022 |
| Priority date | — |
| Expiry date | Apr 10, 2038 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2200/0636
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed is a system and method for production of DNA particles and use thereof. The DNA particles can be produced by amplification of nucleic acid molecule(s). Alternatively, DNA particles can be prepared by condensing multiple DNA molecules. The DNA condensation into a particle is mainly triggered by pyrophosphate and positively charged cations (e.g. magnesium). DNA particles can be applied for numerous biological applications but not limited to directed evolution, proteomics, drug delivery and imaging. DNA particles can be used to synthesize proteins using in vitro transcription/translation reaction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.