Preparation of angiotensin receptor blockers or pharmaceutically acceptable salts thereof

US11327065B1 · kind B1 · utility

Assignee

• Jubilant Generics Limited · IN

Inventors

• Saji Thomas · Savanuru, IN
• Rajendra Singh Shekhawat · Noida, IN
• M. Umamaheshwar Prasad · Noida, IN
• Bidyut Biswas · Sidhauli, IN
• Rohit Chakravarthy · Beavercreek, US
• Chetan Balubhai Patel · Mumbai, IN
• Anilkumar Haribhat Lingabhat · Mumbai, IN
• Mohan Chikmagalur Sadashivappa · Mumbai, IN
• Indranil Nandi · Yardley, US

Key dates

• Filing date: Aug 27, 2021
• Grant date: May 10, 2022
• Expiry date: Aug 27, 2041

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/027
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention relates to a process for the preparation of angiotensin receptor blockers or its pharmaceutically acceptable salts thereof containing less than 10 ppm of the azido impurities. More particularly, the present invention relates to process for the preparation of Losartan, Losartan potassium of Formula I or its other pharmaceutically acceptable salts thereof containing less than 10 ppm of each of the azido impurities, wherein the azido impurity is selected from the group comprising of 5-(4′-(azidomethyl)-[1,1′-biphenyl]-2-yl)-1H-tetrazole, 4′-(azidomethyl)-[1,1′-biphenyl]-2-carbonitrile, 4′-((5-(azidomethyl)-2-butyl-4-chloro-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-carbonitrile, 5-(4′-((5-(azidomethyl)-2-butyl-4-chloro-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)-1H-tetrazole, 5-(azidomethyl)-2-butyl-4-chloro-1H-imidazole, 4′-((4-(azidomethyl)-2-butyl-5-chloro-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-carbonitrile, 5-(4′-((4-(azidomethyl)-2-butyl-5-chloro-1H-imidazol-1-yl)methyl)-[1,1′-biphenyl]-2-yl)-1H-tetrazole and 1-((1-((2′-(1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methyl)-5-(4′-((5-(azidomethyl)-2-butyl-4-chloro-1H…