Method for rapid and quantitative determination of sildenafil in cocktail
US11327085B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 28, 2020 |
| Grant date | May 10, 2022 |
| Priority date | — |
| Expiry date | Jan 7, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/129
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for rapid and quantitative determination of sildenafil in cocktail includes the exemplary steps of: Step 1, assigning a Raman spectrum of sildenafil; Step 2, weighing and dissolving a sildenafil standard in methanol to obtain a 1,000 mg/L sildenafil standard solution, and mixing cocktails with the sildenafil standard solution, to prepare test solutions; Step 3, mixing 100 μL each of test solutions with 500 μL of surface enhancer OTR 202 to acquire Raman spectra; and Step 4, establishing a linear regression model, with a formula of y=4035.1 x+503.26, where y is the content of sildenafil in cocktail, in mg/L, and x is intensity of Raman characteristic peaks at 1584 cm−1. Rapid determination of sildenafil by SERS is feasible and reliable, serving as a novel, rapid, and accurate method for quantitative determination of sildenafil in cocktail. The method meets the requirements of analysis and detection of sildenafil in other alcoholic beverages.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.