Targeted replacement of endogenous T cell receptors

US11331346B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Theodore Lee Roth · San Francisco, US
• Eric Shifrut · San Francisco, US
• Alexander Marson · San Francisco, US
• Cristina Puig Saus · Los Angeles, US
• Antoni Ribas · Los Angeles, US

Key dates

• Filing date: Jul 30, 2021
• Grant date: May 17, 2022
• Expiry date: Jul 30, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.