Preparation method and application of composite scaffold for directionally guiding regeneration of optic nerve axons

US11331413B1 · kind B1 · utility

Assignee

• WENZHOU MEDICAL UNIVERSITY · CN

Inventors

• Kaihui Nan · Wenzhou, CN
• Tonghe Pan · Wenzhou, CN
• Yangjun Chen · Wenzhou, CN
• Jingjie WANG · Wenzhou, CN
• Sen Lin · Shanghai, CN
• Lingli Li · Wenzhou, CN

Key dates

• Filing date: Sep 18, 2020
• Grant date: May 17, 2022
• Expiry date: Sep 18, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/32
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A preparation method and an application of a composite scaffold for directionally guiding regeneration of optic nerve axons. A major component of the composite scaffold is prepared from one or more degradable biomedical materials combined according to different ratios by a gradient freezing method. To increase a mechanical property of the scaffold or prolong in-vivo degradation time, the scaffold may be cross-linked by a biological cross-linker. After a gelatin is added, the prepared composite scaffold exhibits excellent mechanical properties and biocompatibility. A problem of solubility differences of the gelatin A produced during gradient freezing can be regulated by sodium alginate, thereby facilitating regular directional pipeline morphology of the scaffold. After cross-linked with genipin, the composite scaffold significantly enhances stability, and the directional pipeline morphology of the scaffold cam provide attachment sites for regeneration of the optic nerve axons, thereby guiding directional regeneration of the optic nerve axons.