Patent · US Active

Method for producing (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4- chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclo-propylpropanoic acid and the crystalline form thereof for use as a pharmaceutical ingredient

US11332435B2 · kind B2 · utility

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Assignee

Bayer Pharma Aktiengesellschaft · DE

Inventors

Peter Fey · Wuppertal, DE
Philipp Rubenbauer · Bensheim, DE
Kai Lovis · Düsseldorf, DE
Britta Olenik · Bottrop, DE
Julia Küsel · Bochum, DE
Felix Spindler · Starrkirch-Wil, CH

Key dates

Filing date	Nov 26, 2018
Grant date	May 17, 2022
Priority date	—
Expiry date	Nov 26, 2038

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to a novel and improved process for preparing (3S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-3-cyclopropylpropanoic acid of the formula (I), to the compound of the formula (I) in crystalline form and to their use for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular, cardiopulmonary and cardiorenal disorders.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.