Penicillin-binding protein inhibitors

US11332485B2 · kind B2 · utility

Assignee

• VENATORX PHARMACEUTICALS, INC. · US

Inventors

• Christopher J. Burns · Vivonne Bay, AU
• Denis DAIGLE · Street, US
• Guo-Hua Chu · Wilmington, US
• Jodie HAMRICK · New Holland, US
• Matthew C. Lucas · Sunnyvale, US
• Steven A. Boyd · Longmont, US
• Allison L. Zulli · Wayne, US
• Eugen F. Mesaros · Wallingford, US
• Stephen M. Condon · Glenmoore, US
• Robert E. Lee TROUT · Collegeville, US
• Cullen L. MYERS · Exton, US

Key dates

• Filing date: May 25, 2018
• Grant date: May 17, 2022
• Expiry date: May 25, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F5/025
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are certain boron-containing compounds, compositions, preparations and their use as modulators of the transpeptidase function of bacterial penicillin-binding proteins and as antibacterial agents. In some embodiments, the compounds described herein inhibit penicillin-binding proteins. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.