CD73 inhibitors and therapeutic uses thereof

US11332492B2 · kind B2 · utility

Assignees

• JIANGSU HENGRUI MEDICINE CO., LTD. · CN
• SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. · CN

Inventors

• Jian Liu · Los Angeles, US
• Heping Wu · Edison, US
• Linghang Zhuang · Doylestown, US
• Suxing Liu · Edison, US
• Rumin Zhang · Edison, US
• Feng He · Nanhu, CN
• Weikang Tao · Shanghai, CN

Key dates

• Filing date: Aug 28, 2019
• Grant date: May 17, 2022
• Expiry date: Aug 28, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application discloses CD73 inhibitors represented by the general formula (I) and analogs thereof, pharmaceutical compositions containing these compounds, methods of preparing them, and use of these compounds as therapeutic agents for the treatment of diseases or conditions associated with CD73 activity, such as various cancers.